Brewing a Revolution with Fungi: The Next Generation of Cannabinoids

Mushroom Revival Podcast

Researchers at Hyasynth Bio are using fungi to brew cannabinoids such as CBD and THC. Using a method called biosynthesis, the Montreal-based team has engineered brewers yeast to manufacture cannabinoids within their cells. This methods results in compound with a level of potency and purity not previously seen in the cannabis industry.
Today we have the pleasure of speaking with co-founder and metabolic engineer at Hyasynth Bio — Alex Campbell.

Topics Covered:

• Origin story and technology of Hyasynth Bio
• How yeasts can be used as molecular factories
• Metabolic pathways in yeasts and how they can be engineered
• Perspectives on genetic engineering
• Farming cannabinoids with microbes, especially yeasts
• Resource requirements for growing cannabis plants, how that compares to methods in biotechnology
• Slime mold enzymes rendering phytocannabinoid precursors
• Enzyme prospecting and R&D
• CBD, THC and other cannabinoid benefits to human health

Show notes:

• Hyasynth Bio Website: https://hyasynthbio.com/
• Scientists brew cannabis using hacked beer yeast: https://www.nature.com/articles/d41586-019-00714-9
• Newly Risen from yeast: THC : https://www.nytimes.com/2015/09/15/science/newly-risen-from-yeast-thc.html
• Biosynthesis article: https://blog.hyasynthbio.com/what-is-biosynthesis-and-why-do-we-use-it-9ba77284d209
• Charlotte Figi’s Story: https://www.nytimes.com/2020/04/09/us/charlotte-figi-dead.html#:~:text=Charlotte%20became%20the%20face%20of,epilepsy%20that%20starts%20in%20infancy
• Pain, Pus & Poison Documentary series: https://www.bbc.co.uk/programmes/p01f51s5

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