New Era of Highly Targeted Drugs Originating from the Dark Genome: Dr. Samir Ounzain, HAYA Therapeutics

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Can the Dark Genome have the answer to any disease?
And if you are wondering, what is the dark genome, you are not alone. And it is absolutely fascinating.
Some scientists believe that the dark matter of the genome – previously called junk genome – might have the answer to many, many diseases.
With the potential to cure them completely.
Today we are speaking about heart fibrosis and also:

• the richness of the regulatory genome
• its function: as a kind of software for the human body
• RNA therapies that are targeted, non-toxic, fast in development
• an absolutely new approach to drugs

Dr. Samir Ounzain is the CEO of HAYA Therapeutics. A molecular biologist who’s researched dark genome and its roles for over 15 years. While a postdoc at Lausanne University Hospital (CHUV), he discovered hundreds of long-non-coding RNAs.
HAYA Therapeutics selected one of them, called Wisper, to develop a highly targeted drug to address cardiovascular disease. That's for starters. They already work on lung fibrosis, cancer microenvironment, liver, pancreas, and kidney. 3 months after we aired this interview, they signed $1 billion multi-year collaboration with Eli Lilly to target obesity and related metabolic conditions. They are based in both Lausanne, Switzerland and San Diego, US.
https://www.hayatx.com/
Timestamps:
0:00 Dr. Samir Ounzain and HAYA Therapeutics
1:14 Over 90% of Human Genome is Called Dark Genome
7:12 What is the Dark Genome
8:12 What is Epigenetics
11:41 Why Are Humans Different from a Fly
17:56 Most of Chronic Diseases Are Found in Dark Genome
20:17 Types of RNA: Messenger RNA, Non-Coding RNA
26:40 Building the Atlas of Cardiovascular Disease Dark Genome
30:30 Fibrosis and the RNA Called Wisper
38:33 How Can RNAs Be Used As Medicine
42:37 Pre-Clinical Results in Heart Fibrosis: When You Block Wisper RNA
45:22 Start of Studies in Humans of First in Biology Drugs
47:21 HAYA's Atlas of Dark Genome and Search Engine
51:28 HAYA in both Switzerland and the US
58:34 Thank You, Follow HAYA
59:42 Follow X-Health.show, Disclaimer
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Bölümler

1. Dr. Samir Ounzain and HAYA Therapeutics (00:00:00)

2. Over 90% of Human Genome is Called Dark Genome (00:01:14)

3. What is the Dark Genome (00:07:12)

4. What is Epigenetics (00:08:12)

5. Why Are Humans Different from a Fly (00:11:41)

6. Most of Chronic Diseases Are Found in Dark Genome (00:17:56)

7. Types of RNA: Messenger RNA, Non-Coding RNA (00:20:17)

8. Building the Atlas of Cardiovascular Disease Dark Genome (00:26:40)

9. Fibrosis and the RNA Called Wisper (00:30:30)

10. How Can RNAs Be Used As Medicine (00:38:33)

11. Pre-Clinical Results in Heart Fibrosis: When You Block Wisper RNA (00:42:37)

12. Start of Studies in Humans of First in Biology Drugs (00:45:22)

13. HAYA's Atlas of Dark Genome and Search Engine (00:47:21)

14. HAYA in both Switzerland and the US (00:51:28)

15. Thank You, Follow HAYA (00:58:34)

16. Follow X-Health.show, Disclaimer (00:59:42)