EP 116: Genetics and Medicine: Clonal hematopoiesis, genomics in healthcare, and a new discovery in APOL1 kidney disease with Dr. Alex Bick

The Genetics Podcast

0:00 Introduction

4:23 Insights into clonal hematopoiesis from the pioneering Framingham Heart Study

8:30 Linking clonal hematopoiesis to cancer and cardiovascular health

11:22 Interplay of germline and somatic variants in clonal expansion

17:20 How the rate of clonal expansion can provide insights into cancer and cardiovascular risk

19:00 How clonal hematopoiesis interplays with other orthogonal risk factors, including polygenic risk scores, and more established conventional heart health measures

21:00 Integration of genomic data in medical care, leading to the rise of preventative medicine

25:50 Insights into the Vanderbilt Genomics and Therapeutics Clinic

30:00 A dive into the Million Veterans Program, including the discovery of a modifier variant in the APOL1 gene related to kidney disease

44:05 How to differentiate the effects of modifier variants from risk variants in genetic studies

51:00 Individuals with APOL1 loss of function and its implications in kidney health

55:45 Closing remarks