Halie May: the democratization of genomics

Razib Khan's Unsupervised Learning

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State Secrets: Inside The Making Of The Electric State

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The Secret To Getting Inspired: Millie Bobby Brown & Chris Pratt Go Behind The Scenes 21:04

7 weeks önce21:04

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21:04

Step into the mysterious and visually stunning world of The Electric State as host Francesca Amiker takes you behind the scenes with the creative masterminds who brought Simon Stålenhag’s dystopian vision to life. In this premiere episode, directors Joe and Anthony Russo, stars Millie Bobby Brown and Chris Pratt, writers Christopher Markus and Stephen McFeely, and producers Angela Russo-Otstot and Chris Castaldi reveal how they transformed a haunting graphic novel into an epic cinematic experience. Watch The Electric State coming to Netflix on March 14th. Check out more from Netflix Podcasts . State Secrets: Inside the Making of The Electric State is produced by Netflix and Treefort Media.…

1 yıl önce 50:00

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On this episode of Unsupervised Learning Razib talks to Halie May, the host of the Substack The Sequence, and a genetic counselor at Natera. May has a B.S. in chemical biology from Stevens Institute of Technology and a M.S. in human genetics from Sarah Lawrence. Before working at Natera she was a researcher and instructor at Columbia University and designed testing panels at genetics start-up, Tomorrow’s Health.

Razib and May discuss how much the field has changed even in her short career, in large part because genetic counseling is a 50-year-old profession that has been transformed in the last decade by the introduction of genome-wide datasets. May highlights the changes in the last ten years, and how they have impacted counselors and end users, in particular the ubiquity of noninvasive prenatal screening tests. Here, she mentions that whole-genome analysis isn’t quite where she had expected when she began studying these issues six years ago, and Razib brings up the fact that it’s already a decade ago he had his son whole-genome sequenced. They discuss the hold-ups in the progress of genetic testing and analysis, and May points out that a major issue is likely the utter lack of federal guidelines, with oversight of genetic healthcare mostly being left to the states. This lack of coordination means that there is no top-down signal, and localities and institutions are left to cobble together frameworks in an ad hoc manner. Razib also asks May about how private companies, like Natera, might fill the gap in what hospitals can provide, and the potential pathways and promise of the democratization of genetic results.

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#Biology #Social Sciences #Culture #Politics #Genetics #Science #Natural Sciences #History #Society #Razib Khans

Halie May: the democratization of genomics

Razib Khan's Unsupervised Learning

329 subscribers

published 1 yıl önce

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245 bölüm

#Biology #Social Sciences #Culture #Politics #Genetics #Science #Natural Sciences #History #Society #Razib Khans

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Razib Khan's Unsupervised Learning

1
Andrew Song: cooling the planet with technology 55:04

3 gün önce55:04

55:04

On this episode of Unsupervised Learning , Razib talks to Andrew Song , co-founder of Make Sunsets . An NYU graduate with a degree in economics, Song was a member of the Y Combinator class of winter 2016. Before becoming a founder, Song worked at firms involved in data analytics and artificial intelligence. A repeat attendee at the Founders Fund “Hereticon” conference, Song’s company has been profiled IEEE Spectrum , The New York Times and NPR . Razib and Song first talk about the current state of climate, or more precisely, climate change and anthropogenic global warming. Song argues that the emission-reduction strategy has fundamentally failed, and global warming is inevitable absent a drastic strategy shift. Enter geoengineering, the deliberate large-scale manipulation of an environmental process that affects the earth. In the context of global warming Song proposes that humans engage in proactive efforts to cool the world. His company, along with a similar Israeli startup, proposes to introduce particulate matter into the stratosphere to reflect back some of the sun’s radiation. Razib asks Song what the reaction has been, given that the atmosphere is a public resource, and how he proposes to eventually make it a revenue-generating business through government contracts. More generally, Razib and Song talk about other geoengineering projects, including Augustus Doricko’s dream of increasing precipitation through his Rainmaker firm.…

Razib Khan's Unsupervised Learning

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Zineb Riboua: realism in foreign policy in 2025 1:07:28

9 gün önce1:07:28

1:07:28

Today on Unsupervised Learning Razib talks to Zineb Riboua , a research fellow and program manager of Hudson Institute’s Center for Peace and Security in the Middle East. She specializes in Chinese and Russian involvement in the Middle East, the Sahel, and North Africa, great power competition in the region, and Israeli-Arab relations. Riboua’s pieces and commentary have appeared in the Wall Street Journal, Foreign Policy , the National Interest , the Jerusalem Post and Tablet among other outlets. She holds a master’s of public policy from the McCourt School of Public Policy at Georgetown University. She did her undergraduate studies in France, where she attended French preparatory classes and HEC Paris’ Grande Ecole program. Her Substack is Beyond the Ideological . Razib and Riboua discuss the Trump administration’s theory of tariffs as a tool of foreign policy and his attitudes toward multilateral diplomacy. They explore whether any principle beyond power and dominance underlies the current administration’s approach, and consider the role of principles and values in foreign policy. Riboua elaborates a realist perspective in line with the thinking of Henry Kissinger. States have interests and abilities to execute on those interests; idealism is secondary. Riboua also discusses the fact that Trump seems attuned to how foreign politicians relate to the American domestic scene. He seems willing to punish those abroad whom he perceives to be favorable to his political enemies and reward those who are personally favorable toward him. Razib then asks Riboua about the geopolitics of her native Morocco, a relatively stable monarchy on northwest Africa’s edge that has promoted moderate Islam, a good relationship with Europe and maintained a stable democracy.…

Razib Khan's Unsupervised Learning

1
Mark Lutter: charter cities and the urban future 1:03:03

20 gün önce1:03:03

1:03:03

On this episode of Unsupervised Learning Razib talks to Mark Lutter. Lutter is an urban development expert known for his work on charter cities—new urban areas aimed at fostering economic growth and progress. He is the Founder and Executive Chairman of the Charter Cities Institute, a nonprofit dedicated to building the ecosystem for charter cities, as well as the CEO of Braavos Cities, a charter city development company. He holds a PhD in economics from George Mason University, and a BS in mathematics from the University of Maryland, College Park. His interests span progress studies, governance, social dynamics and institution-building, with a belief that creating new cities can spark cultural and economic advancements similar to historical periods like the Renaissance or the Dutch Golden Age. He has been published or quoted in outlets like the Financial Times , The New Yorker , and The Chicago Tribune . Lutter and Razib discuss diverse topics, from the difficulties of the Prospera project in Honduras, to the possibility of developing San Francisco’s Presidio into an Asian-style super-city. They explore the various pitfalls and possibilities faced when attempting to create new jurisdictions in developing nations in the Caribbean and Latin America, along with the major obstacles to urban innovation in the USA. Lutter outlines the economic case for charter cities, along with the normative values that undergird their creation as bastions of liberty and laboratories of cultural experimentation. Finally, they discuss the Trump administration’s openness to the idea of the “Freedom City” in the Presidio, along with local opposition to the project.…

Razib Khan's Unsupervised Learning

1
Graeme Wood: Germany's turn to the right 1:05:30

29 gün önce1:05:30

1:05:30

On this episode of Unsupervised Learning, Razib talks to Graeme Wood. Wood is a staff writer at The Atlantic , where he usually covers geopolitics and international affairs. His work ranges from a profile of Richard Spencer , the American white nationalist public figure with whom he went to high school with, to the Islamic State . He is the author of The Way of the Strangers: Encounters with the Islamic State . Wood grew up in Dallas, Texas, and graduated from Harvard College. He also studied at the American University in Cairo, Indiana University and Deep Springs College. Today Razib talks to Wood about his piece in The Atlantic, Germany’s Anti-Extremist Firewall Is Collapsing . Wood addresses the economic malaise of contemporary Germany, in particular, the former East Germany, and how that is impacting the national cultural climate. More concretely, they consider why the right-wing Alternative For Deutschland (AFD) party is so popular, and its transformation from an anti-EU party to an anti-migrant party. Wood emphasizes that Germany has become a highly polarized society when it comes to ethnicities, with very cosmopolitan cities, but small towns in rural eastern provinces where he recalls feeling like possibly the only non-white face at the local beer hall (his father is a white American while his mother is ethnically Chinese). Razib muses whether German multiculturalism as an ideology has allowed for more, not less racism, while Wood reflects on his multi-decade experience visiting the nation as an outsider.…

Razib Khan's Unsupervised Learning

1
Leighton Woodhouse: against the rise of the anti-woke cancel culture and MAGA cultural hegemony 1:27:09

5 weeks önce1:27:09

1:27:09

On this episode of Unsupervised Learning Razib welcomes Leighton Akira Woodhouse back to the podcast for his third visit . Woodhouse is a journalist and documentarian based in Oakland, California. He grew up in Berkeley, and was a doctoral student in Sociology at UC Berkeley. After leaving academia he contributed to outlets like The Intercept, UnHerd and The Nation, before starting his own Substack, Social Studies . He hosts Le Pod with Lee Fang . Woodhouse was a major left-wing critic of the excesses of woke culture, and now he has turned his skeptical eye upon the regnant MAGA cultural political complex. In posts like MAGA Globalism and Neoliberalism is Back! Woodhouse observes how the Trump administration seems to have turned its back on the “working-class politics” espoused by J. D. Vance in favor of the sort of free-market libertarianism preferred by tech oligarchs like Elon Musk. Razib outlines the divisions in the Trump administration between Steve Bannon and the tech-globalists around Musk, and how these divisions explain online discord. Woodhouse though argues that Trump has clearly sided with Musk, allowing the government to be captured by monied interests that will profit from the military-industrial complex. He also argues that MAGA in power shows the same tendency of the woke movement in terms of clamping down on free speech now that the Right is ascendant. Woodhouse argues that the Right is now using the same tools of cultural hegemony that the woke Left used before 2024. He argues that institutional politicization today is very similar to the dynamic he saw before 2024 on the part of the woke Left.…

Razib Khan's Unsupervised Learning

1
Kevin Klatt: Nutrition, health, MAHA and GLP-1 1:20:04

6 weeks önce1:20:04

1:20:04

On this episode of Unsupervised Learning Razib talks to Kevin Klatt , a metabolism researcher , dietitian and science communicator . Klatt holds a BA in biological anthropology from Temple University and a PhD in Molecular Nutrition from Cornell University. Before a current appointment as a research scientist at UC Berkeley, he was a postdoctoral fellow at Baylor College of Medicine. Klatt’s primary platform to communicate about nutrition, health and molecular biology is his Substack . He is also an associate editor at the American Journal of Clinical Nutrition . Recently Klatt has been writing about the “MAHA” pivot, “Make America Healthy Again,” driven by RFK Jr.’s appointment as head of Health and Human Sciences. Razib and Klatt talk about new directions driven by RFK Jr.'s focus on preventative health and skepticism of pharmaceuticals. Klatt points out that the past two decades have seen a massive shift away from funding nutritional studies, in contrast to the massive budgets of big pharma. He argues that we now really find ourselves without enough information to outline a public health policy given the underfunding of nutritional cohort studies. If MAHA is going to be a serious movement, it needs to drive a reallocation of funds. Razib and Klatt also touch on the cultural shift over the last decade on the Right, where something like “raw milk” switched from being coded as left-wing to being squarely right-wing. They also consider mounting skepticism of mainstream medicine, including vaccination, that seems to be associated with MAHA and in particular RFK Jr. Klatt also addresses the role that GLP-1 drugs are having in driving down obesity rates in the USA, and how pervasive their use might be in the near future.…

Razib Khan's Unsupervised Learning

1
Charles Murray: 50 years on the public scene 59:57

7 weeks önce59:57

59:57

On this episode of Unsupervised Learning , friend of the podcast, Charles Murray returns to chat with Razib again. Murray has been a public intellectual and scholar since the 1970’s. He is the author of Losing Ground , The Bell Curve , Human Accomplishment , Real Education , Coming Apart and What it means to be a libertarian and Human Diversity , among others. Born in 1943 in Newton, Iowa, Murray has a BA from Harvard, an MA and PhD from MIT, and did a 1960’s stint in the Peace Corps in Thailand. He has held positions at the American Institutions for Research, the Manhattan Institute and the American Enterprise Institute. More than four years after their last conversation , and seven years after his official retirement, Murray reflects with Razib on where he sees America going in the next decade, and what has surprised him about the last 25 years. Razib asks what it is like to be a long-standing “Never Trump conservative” and a libertarian in Trump’s populist America. They also discuss the end of the “awokening” that began in the mid-2010s, and whether Murray’s long exile from notice and acknowledgement from mainstream opinion-leaders and tastemakers is at an end. Murray also addresses the ideological fractures he sees on the right, and how America will deal with the last generation of mass immigration that has altered the US’ demographic balance. They also discuss how taboo it still is to talk about group differences in cognitive performance, and whether America will be able to face the reality of demographics and the social consequences thereof in the 21st century.…

Razib Khan's Unsupervised Learning

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Titus Techera: Post-Modern Conservative in a post-national Europe 1:26:24

8 weeks önce1:26:24

1:26:24

On this episode of Unsupervised Learning , Razib talks to Titus Techera , a Romanian living in Budapest, but commenting extensively on American and European culture. He is the Executive Director of the American Cinema Foundation, International Coordinator of the National Conservatism Conference and is a primary contributor to the Substack PostModernConservative . Techera also hosts a podcast for the American Cinema Foundation. Razib first talks to Techera about the 2024 Romanian presidential election that was overturned by the courts over accusations of Russian interference. Techera explains the social and cultural context of the candidate initially declared victorious against a backdrop of Romanian society’s typical stock characters. Techera also discusses the tension between having a nation-state with a distinctive character and becoming part of the broader EU project that is attempting to forge unity across 27 countries. He then addresses what a “Postmodern Conservative” is in the context of the arts. Perhaps most importantly, PostModern Conservatives take the 20th century and the modernist period seriously; they are not simply reactionaries who want to return to the 19th century. Conservatives who value the arts and culture cannot simply roll the tape back; they have to engage with what has come before. Razib and Techera also consider how inferences from the sciences, like the rejection of the “blank slate,” might influence the arts. They also discuss their disagreements about the latest Dune films, Techera prefers David Lynch’s attempt to adapt the book in 1984 to Denis Villeneuve’s 2021 version.…

Razib Khan's Unsupervised Learning

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Nathan Lents: Sex, truths and gender wars 2:09:01

8 weeks önce2:09:01

2:09:01

On this episode of Unsupervised Learning Razib talks to Nathan Lents about his new book, The Sexual Evolution: A Provocative Look at Sexual Behavior Through the Lens of Evolution . A professor at John Jay College in New York City, Lents earned a Ph.D. in Pharmacological and Physiological Sciences in 2004 at Saint Louis University School of Medicine, and did his postdoctoral fellowship in cancer genomics at NYU Medical Center. Lents’ research ranges from the evolution of molecular mechanisms to behavioral ecology. He is also the author of Not So Different: Finding Human Nature in Animals and Human Errors: A Panorama of Our Glitches, from Pointless Bones to Broken Genes . Lents reached out to Razib after hearing his podcast with Conn Carroll , about his book Sex and the Citizen: How the Assault on Marriage Is Destroying Democracy . Lents felt that Carroll overemphasized the role of monogamy during humanity’s long forager phase, and more precisely, failed to distinguish social monogamy and genetic monogamy. As noted in The Sexual Evolution , many socially monogamous species, like most birds, engage in enough extra-pair copulation so that genetic fidelity is considerably lower than 100%. Razib and Lents then go back to first principles, talking about the origins of sex, and its persistence in the face of the two-fold cost of reproduction in dimorphous organisms. They discuss why specialized males and females exist in complex organisms as distinct as flowering plants and humans. Lents also discusses the reviews empirical literature on homosexual behavior, variation in sex differences across many classes of organisms and the application of evolutionary thinking to our understanding of the human past. Then they discuss the relevance of evolutionary biology for understanding the human present, and our current debates about marriage, sex and gender. Finally, they consider the differences between sex and gender, and the idea that both can be conceptualized in a nonbinary fashion.…

Razib Khan's Unsupervised Learning

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Antonio Regalado: CRISPR babies 6 years later 1:16:44

8 weeks önce1:16:44

1:16:44

Today Razib talks to Antonio Regalado , reporter at MIT Technology Review . Regalado covers how technology is changing medicine and biomedical research. Before joining MIT Technology Review in 2011, he lived in São Paulo, Brazil, where he wrote about science, technology, and politics in Latin America for Science and other publications. From 2000 to 2009, he was a science reporter and foreign correspondent at the Wall Street Journal . Among the many stories Regalado has broken was the prenatal sequencing of Razib’s son in 2014, but on this episode they talk about another scoop: his 2018 reporting on the “CRISPR babies” (listen to a podcast on the topic with Regalado on The Insight ). Starting in 2024, the scientist who led the 2018 gene-editing of two babies in China, He Jiankui, seemed to embrace a new role as self-appointed social media evangelist and oracle, mostly about his own future. Regalado talks about what he thinks the Chinese scientist is up to, where the field of CRISPR-gene editing is at present and where it is going. Razib and Regalado also discuss the rise and fall, and future prospects, of CRISPR biotech startups attempting to develop therapies that deploy gene-editing. Regalado also muses on the emergence of companies that provide genomic technologies and services like embryo screening in the “gray market” away from public view.…

Razib Khan's Unsupervised Learning

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Daniel McCarthy: American conservatism after Trump (and before) 1:03:05

8 weeks önce1:03:05

1:03:05

On this episode of Unsupervised Learning Razib talks to Daniel McCarthy, editor-in-chief of Modern Age . Former editor-in-chief of The American Conservative , his writing has also appeared in the New York Times , USA Today , The Spectator , The National Interest and Reason . McCarthy also helped run communications for the 2008 Ron Paul campaign and was a senior editor at ISI Books. He earned a Ph.D. in classics from Washington University in St. Louis. First, Razib and McCarthy discuss the outcome of the 2024 presidential election, and the realignment of coalitions on both right and left, and what these realignments might presage for both parties’ future. McCarthy also outlines the long march of anti-war conservatives who organized themselves around The American Conservative in the first George W. Bush term, their eventual move into the mainstream and poll position in the discourse under Donald Trump. Razib asks about the origins of modern conservatism’s divisions, going back to William F. Buckley’s founding of National Review in the 1950’s. McCarthy also talks about Russell Kirk’s role in the development of post-World War II conservatism, which included the founding of Modern Age , a more intellectual and philosophical publication than National Review . Razib asks McCarthy how the Right will evolve in a changing America, with a diminishing white majority and a more post-Christian mainstream. This episode is live on Substack 14 days before it premieres on Youtube. For early access, feel free to explore it there. https://www.razibkhan.com/p/daniel-mccarthy-american-conservatism…

Razib Khan's Unsupervised Learning

1
Tade Souaiaia: the edge of statistical genetics, race and sports 1:10:34

9 weeks önce1:10:34

1:10:34

On this episode of Unsupervised Learning Razib talks to Tade Souaiaia , a statistical geneticist at SUNY Downstate about his new preprint, Striking Departures from Polygenic Architecture in the Tails of Complex Traits . Souaiaia trained as a computational biologist at USC, but also has a background as a division I track and field athlete. Razib and Souaiaia discuss what “genetic architecture” means, and consider what we're finding when we look at extreme trait values in characteristics along a normal distribution. Though traits like height or risk for type II diabetes can be thought of as represented by an idealized Gaussian distribution, real molecular and cellular processes still underlie their phenotypic expression. Souaiaia talks about how genomics has resulted in an influx of data and allowed statistical geneticists with a theoretical bent to actually test some of the models that underpin our understanding of traits and examine how models like mutation-selection balance might differ from what we’ve long expected. After wading through the depths of genetic abstraction and how it intersects with the new age of big data, Razib and Souaiaia talk about race and sports, and whether there might be differences between groups in athletic ability. Souaiaia argues that the underlying historical track record is too variable to draw firm conclusions, while Razib argues that there are theoretical reasons that one should expect differences between groups at the tails and even around the memes.…

Razib Khan's Unsupervised Learning

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Shadi Hamid: pessimism on Palestine but hope in America 1:20:47

10 weeks önce1:20:47

1:20:47

On this episode of Unsupervised Learning Razib talks with Washington Post columnist Shadi Hamid. A native Pennsylvanian of Egyptian ethnic background, and Islamic faith, Hamid completed his Ph.D. in politics at Oxford University. He is an assistant professor at Fuller Seminary , co-host of the Wisdom of Crowds podcast and website, and now the author of his own Substack and a recent book, The Problem of Democracy: America, the Middle East, and the Rise and Fall of an Idea . Hamid is also the author of Temptations of Power: Islamists & Illiberal Democracy in a New Middle East and Rethinking Political Islam . Hamid and Razib discuss the tail end of the war in Gaza, from the explosion of 10/7 and the wave of atrocities against Israelis surrounding the Palestinian enclave, to the brutal counter-attack that has resulted in tens of thousands of Gazan civilian deaths. While Hamid points to the deep structural issues that divide the two parties, and make final resolution of the conflict difficult, Razib highlights the many pitfalls of third parties becoming involved in such a highly polarized and fraught topic. They also discuss the growing identification of the global Left, including American progressives, with the Palestinian cause, the difficulties of grappling with and containing anti-Semitism within the movement. Though Israel’s counter-offensive is finally reaching a denouement, Hamid strikes a fundamentally pessimistic note about long-term possibilities. Then they pivot to domestic politics, and recent cultural trends that culminated in a Trump victory in the 2024 USelection, and the alienation of many nonwhites in the Democratic coalition from the hegemony of woke cultural elites. Hamid reiterates his long-standing critiques of racial identitarianism on the Left, and the irony that the progressive awareness of racial minorities only tends to extend to them when these minorities cosign woke nostrums. In contrast to the seemingly interminable nature of the conflict in the Middle East, Razib and Hamid both see hope for a path forward with reduced racial polarization and a reorientation of politics around substantive material interests rather than symbolic racial or ethnic categories.…

Razib Khan's Unsupervised Learning

1
Conn Carroll: Sex and the Citizen 1:14:13

11 weeks önce1:14:13

1:14:13

On this episode of Unsupervised Learning Razib talks to Conn Carroll , the author of Sex and the Citizen: How the Assault on Marriage Is Destroying Democracy . Caroll is currently an editor for the Washington Examiner , but previously he was the communications director for Senator Mike Lee of Utah, an assistant director at the Heritage Foundation, White House correspondent for Townhall.com and a reporter at National Journal . Carroll wrote Sex and the Citizen in response to what he felt was misleading and biased reporting in the mainstream media on the origins and implications of marriage and monogamy. Razib asks Carroll how he refutes the ideas presented in Christopher Ryan and Cacilda Jethá’s Sex at Dawn , which argues that prehistoric humans were non-monogamous. Carroll outlines the current mainstream thinking in evolutionary anthropology and primatology, and all the biological reasons that indicate that Homo sapiens is far more monogamous than our common chimpanzee and gorilla cousins, most clearly in our reduced sexual dimorphism. But while our hunter-gatherer past was defined by monogamy, Sex and the Citizen argues that the rise of agriculture resulted in the explosion of polygamy, as high status males in societies defined by incredible inequality began to monopolize access to women, culminating in the explosion of Y chromosomal “star phylogenies,” where supermale lineages exploded all over Eurasian 4,000 years ago. Carroll then explains that the Romans and Greeks took steps toward enforcing monogamy as a legal institution, and Christianity introduced the idea of sexual fidelity upon men. After Christianity popularized egalitarian monogamous marriage, Sex and the Citizen follows in Joe Henrich’s wake in The WEIRDest People in the World: How the West Became Psychologically Peculiar and Particularly Prosperous . Carroll discusses the Catholic Church’s strict policies on incest and adoption, which destroyed the power of elite related clans in the West, and hastened the emergence of the Western European marriage norm of independent and separate nuclear families, rather than extended families as the primary unit of kinship in society. In the second half of Sex and the Citizen Carroll addresses the social history and policy changes in relation to marriage in the US. While Western European societies took a significant step away from familialism, Carroll explains that American marriage was even more individualistic and radical, as nuclear families spread out to the frontier, away from their extended kin networks. He also contextualizes the rise of the 1950’s nuclear family, which some scholars have argued was an aberration in American history. Carroll argues that actually it was an extension of earlier American norms, but the rise of the wage-based capitalist economy allowed for couples to set up separate households earlier in their lives. Carroll concludes the discussion outlining the 1970’s policy changes in welfare provision that discouraged marriage, noting the decline of the institution across American society over the last 60 years, and how government policy might reverse it.…

Razib Khan's Unsupervised Learning

1
Dan Hess: the fertility collapse 1:44:34

12 weeks önce1:44:34

1:44:34

On this episode of Unsupervised Learning Razib has a wide-ranging conversation with Dan Hess, the man behind the More Births account on social media. An engineer with a large family in the DC area, Hess’ essays on topics like Israelis’ high birth rate have gained the attention of X, with an account that has come from a few hundred followers to more than 30,000 in 2 years. Razib and Hess first review the birth-rate collapse seen worldwide in the past two decades. They discuss the relatively abrupt cultural pivot that has occurred since the turn of the century, with the end of the “overpopulation” narrative typified by Paul Erhlich’s Population Bomb , the rise of the “birth dearth” and the natalist movement. They talk about the most extreme cases of low total fertility rates (TFR) in Europe and East Asia, but also the decline in societies like the US, Latin America and the Middle East. Hess addresses both possible causes and possible solutions. They also discuss historical and demographic factors that impact fertility; for example, which religions have been the most pro-natalist? Hess also puts a particular focus on South Korea, the world’s most extreme case of a sharp decrease, with a TFR of about 0.70 children per woman (vs. 2.1 replacement), as well as exceptions to the rule like Haredi Jews and the Amish. Finally, Razib and Hess tackle why we should care about slower population growth in this century, from dependency ratios to the impact on cultural vitality.…

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