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Music and comedy written & produced at Poison Dart Studios, Baltimore. Songs that say "cover" are covers, the rest are original, with instruments and vocals performed by me. The Reigning Lunatic podcast (2015-16) was a Parsec Award Finalist. A scripted sitcom in 9 episodes, set in a despotic medieval kingdom plagued by dragons, wizards, and dreadful wifi. Written by GW, created by GW & Betty Welchman, featuring a cast of several. The Inverse Delirium podcast (2010-14) was a short, sharp sati ...
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Two critical care guys walk into a recording studio and breakdown intensive care trials both old and new! We'll also do deep dives on specific topics important to practicing intensive care medicine and have special guests talking about their area of expertise! This podcast is made for educational purposes. The content provided in this podcast, and in any linked materials, is not intended and should not be construed as medical advice and should not be used to diagnose or treat any medical con ...
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Send us a Text Message (please include your email so we can respond!) We are LIVE at CHEST2024! Thank you to the organizers of the conference for inviting us do a live show and thank you to everyone who came out to listen! We talk about a few articles that were recently published in CHEST - "Prophylactic Minocycline for Delirium in Critically Ill P…
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Send us a Text Message (please include your email so we can respond!) Episode 48! In this episode we talk about the long term effects of ICU visitation policies on families. Long Term Outcomes of Visitation (pubmed): https://pubmed.ncbi.nlm.nih.gov/39172240/ Long Term Outcomes of Visitation (ICM): https://link.springer.com/article/10.1007/s00134-02…
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Send us a Text Message (please include your email so we can respond!) Episode 47! In this episode we talk about a prospective observational study examining cognitive motor dissociation by Bodien et al published in the New England Journal of Medicine and then we pair that talking about the guidelines for death by neurologic criteria published in SCC…
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Send us a Text Message (please include your email so we can respond!) Episode 46! In this episode we talk about thrombolytic windows in acute ischemic stroke from TIMELESS published by Albers et al published in the New England Journal of Medicine and then we talk about ANDROMEDA shock and serial lactates published by Hernandez et al! TIMELESS (pubm…
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Send us a Text Message (please include your email so we can respond!) Episode 45! In this episode we talk about sepsis bundles and the 1-BED trial by Fruend et al and discuss the stress ulcer prophylaxis guidelines just published in SCCM! 1-BED (pubmed): https://pubmed.ncbi.nlm.nih.gov/38913098/ SUP Guidelines: https://www.sccm.org/Clinical-Resourc…
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Send us a Text Message (please include your email so we can respond!) We were honored to be joined by Joanna Stollings (and honestly we needed someone to keep us grounded) to talk about BLING3 or "Continuous vs Intermittent β-Lactam Antibiotic Infusions in Critically Ill Patients With Sepsis" published in JAMA by Dulhunty et al and also released wi…
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Send us a Text Message (please include your email so we can respond!) Episode 43! In this episode come close to finishing our dedicated discussion of the CCR24 trials talking about transfusion targets in TBI (HEMOTION) and dapagliflozin in critical illness (DEFENDER)! HEMOTION: https://www.nejm.org/doi/full/10.1056/NEJMoa2404360 HEMOTION (pubmed): …
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Send us a Text Message (please include your email so we can respond!) Episode 42! In this episode we foray into weight lifting and body building as we talked about amino acids for kidney protection after cardiac surgery (PROTECTION) and cycling in addition to PT in mechanically ventilated adults (CYCLE). We also feature our first real ad for the Cr…
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Send us a Text Message (please include your email so we can respond!) Episode 41! We continue our CCR24 recap with a brief overview and thoughts on the conference as a whole and then dive into REVISE or "Stress Ulcer Prophylaxis during Invasive Mechanical Ventilation" published by Cook et al in NEJM June 2024. Not the sexiest of all the topics but …
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Send us a Text Message (please include your email so we can respond!) Episode 40! In this special episode releasing at the conclusion of the PREOXI presentation at the Critical Care Reviews 2024 conference in Belfast, Ireland - we discuss the recently published PREOXI trial evaluating NIV vs facemask as pre-oxygenation for emergent endotracheal int…
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Send us a Text Message (please include your email so we can respond!) Episode 39! In this episode we talk about steroids in septic shock from community acquired pneumonia - a secondary from the APROCCHSS trial. We then dive into our mailbag to talk about a couple of topics we've been asked questions about and address them in a more broad sense. A p…
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Send us a Text Message (please include your email so we can respond!) We're live from ATS! We decide to format our episode after the NEJM/JAMA/ATS combined session and talk about the articles presented there. Some of them we've talked about before but provide new insights from listeners and questions from the audience. Some of them are new and we p…
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Send us a Text Message (please include your email so we can respond!) Episode 37! In this episode we talk about glycemic control in the ICU. We liked the flipped script and so we're again going old article first. NICE-SUGAR or "Intensive versus conventional glucose control in critically ill patients" was published in NEJM 2009 and then we talk abou…
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Send us a Text Message (please include your email so we can respond!) Episode 36! In this episode we talk about tranexamic acid in GI bleeds. We flip the script a little bit and talk about our OLD article first, HALT-IT or "Tranexamic acid in upper gastrointestinal bleed in patients with cirrhosis: A randomized controlled trial" published in Lancet…
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Send us a Text Message (please include your email so we can respond!) Episode 35! In this episode we talk about extubation practices with "Effect of aggressive vs conservative screening and confirmatory test on time to extubation among patients at low or intermediate risk: a randomized clinical trial" published in Intensive Care Medicine by Hernand…
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Send us a Text Message (please include your email so we can respond!) Episode 34! In this episode we talk about oxygen targets! Specifically we go over the two oxygen target analyses that were published simultaneously with ISICEM. We spend most of our time with HOT-COVID published by Nielson et al and then dip a little into individualized treatment…
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Send us a Text Message (please include your email so we can respond!) Episode 33! In this episode we are excited to be joined by Eddy Fan and Whitney Gannon, two extraordinary ECMO researchers to talk about VENT-AVOID or " Extracorporeal Carbon Dioxide Removal to Avoid Invasive Ventilation During Exacerbations of Chronic Obstructive Pulmonary Disea…
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Send us a Text Message (please include your email so we can respond!) Episode 32! We got a lot of feedback on our last episode so we decided to address it in a full episode! A lot of listeners asked us about vasopressors specifically vasopressin and angiotensin-2 so we talk about VASST, VANISH, and ATHOS-3. It is a full episode but a good one! VASS…
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Send us a Text Message (please include your email so we can respond!) Episode 31! This episode we talk first about invasive vs non-invasive blood pressures from an observational paper titled "Accuracy of Noninvasive Blood Pressure Monitoring in Critically Ill Adults" published in journal of Intensive Care Medicine by Haber et al and then for our ol…
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Send us a Text Message (please include your email so we can respond!) Episode 30! This episode is a little different. We recap the SCCM conference first. THEN we go into PROPHY-VAP or "Ceftriaxone to prevent early ventilator-associated pneumonia in patients with acute brain injury" published January 2024 by Professor Dahyot-Fizelier in Lancet Respi…
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Send us a Text Message (please include your email so we can respond!) Episode 29! We stray a little bit from our new and old article structure to talk about two recently published but slightly different ARDS recommendations from ATS and ESCIM. We compare and contrast them and give our takes on the data and evidence. Thanks to everyone who emails in…
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Send us a Text Message (please include your email so we can respond!) Episode 28! In this episodes we talk about ECMO! PRONECMO evaluated the effect of prone positioning on patients already on ECMO by Schmidt et al in JAMA December 2023 and then EOLIA by Combes et al in NEJM 2018 which is our old article which randomized patients to ECMO or not. Gr…
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Send us a Text Message (please include your email so we can respond!) Episode 27! In this episodes we sit down to talk all about the "when" to intubate a patient centered around acute poisoning in the NICO trial or "Effect of Noninvasive Airway Management of Comatose Patients With Acute Poisoning: A Randomized Clinical Trial" published by Freud et …
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Send us a Text Message (please include your email so we can respond!) This was easily our most requested article to discuss and for good reason - Eddie and Todd recently published the ACORN trial or "Cefepime vs Piperacillin-Tazobactam in Adults Hospitalized With Acute Infection" in JAMA October 2023. We recognize our bias as the first and last aut…
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Send us a Text Message (please include your email so we can respond!) Episode 25! In this episode we talk about the MINT trial or "Restrictive or Liberal Transfusion Strategy in Myocardial Infarction and Anemia" published in NEJM November 2023 by Carson et al. We supplement this with a recent observational cohort study that gives Todd anxiety title…
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Send us a Text Message (please include your email so we can respond!) Episode 24! Three trials about COVID were published with ESICM which we talk about all three here. COVID has been decreasing in prevalence in our ICU at least so we anchor our discussion around what we can learn from these trials about ARDS in general or what we can carry forward…
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Send us a Text Message (please include your email so we can respond!) Episode 23! We spend a little bit of time talking about our recent conference related travel and food experience but dive into our coverage of the trials that released with ESICM including "Inhaled Amikacin to Prevent Ventilator-Associated Pneumonia" by Ehrmann et al published in…
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Send us a Text Message (please include your email so we can respond!) Episode 22! In this episode we talk about "Peripheral Administration of Norepinephrine: A Prospective Observational Study" published August 2023 by Yerke et al in CHEST. For our old article we talk about "Effect of midodrine versus placebo on time to vasopressor discontinuation i…
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Send us a Text Message (please include your email so we can respond!) Live show? Thank you so much to the organizers of the ACNP/PA Critical Care Bootcamp who invited us to do a live episode of the show! We talked about the AKIKI2 trial "Comparison of two delayed strategies for renal replacement therapy initiation for severe acute kidney injury" by…
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Send us a Text Message (please include your email so we can respond!) Episode 21! In this episode we talk about "Extracorporeal Life Support in Infarct-Related Cardiogenic Shock" published August 2023 by Thiele et al in NEJM. Then we dive into our neglected mail bad to try to answer some listener questions. ECLS-SHOCK: https://pubmed.ncbi.nlm.nih.g…
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Send us a Text Message (please include your email so we can respond!) Episode 20! In this episode we talk about "Effect of Selective Decontamination of the Digestive Tract on Hospital Mortality in Critically Ill Patients Receiving Mechanical Ventilation" published October 2022 by the ANZICS group in JAMA. We have the first author and senior authors…
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Send us a Text Message (please include your email so we can respond!) Episode 19! In this episode we talk about "Oxygen-Saturation Targets for Critically Ill Adults Receiving Mechanical Ventilation" published November 2022 by Semler et al in the New England Journal of Medicine. We have the first author, Matt Semler, on with us to talk to us about t…
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Send us a Text Message (please include your email so we can respond!) Episode 18! In this episode we talk about "Early adjunctive methylene blue in patients with septic shock: a randomized controlled trial" published March 2023 by Ibarra-Estrada et al in Critical Care. We made a planning mistake so no old article today so we left it short! Methylen…
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Send us a Text Message (please include your email so we can respond!) Episode 17! In this episode we talk about "Aggressive of Moderate Fluid Resuscitation in Acute Pancreatitis" published September 2022 by de-Madaria et al in the New England Journal of Medicine and then talk about the landmark study "Early Goal-Directed Therapy in the Treatment of…
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Send us a Text Message (please include your email so we can respond!) Episode 16! In this episode we talk about "Phenobarbital-Based Protocol for Alcohol Withdrawal Syndrome in a Medical ICU: Pre-Post Implementation Study" published April 2023 by Alwakeel et al and then talk about the landmark study TRICC or "A multicenter, randomized, controlled c…
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Send us a Text Message (please include your email so we can respond!) Episode 15! In this episode we talk about "Blood-Pressure Targets in Comatose Survivors of Cardiac Arrest" published October 2022 by Kjaergaard (apologies in advance for the pronounciation...) et al and then talk about the prospective observational cohort "Weaning from mechanical…
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Send us a Text Message (please include your email so we can respond!) Summer is here and we're getting a chance to catch our breath! Unless there is a surprise article drop we anticipate that our next few episodes are going to be a little bit different as we catch up on non-RCT happenings in the critical care world. This episode is the same, our di…
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Send us a Text Message (please include your email so we can respond!) Episode 13! We made it this far! Instead of keying in on one major article from the Critical Care Reviews Conference 2023 we decided to do a pot pourri of the entire conference. It was quite the whirlwind, if there is any point or trial you want us to elaborate please contact us …
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Send us a Text Message (please include your email so we can respond!) This is a little off schedule (and a little long!) but we were SO EXCITED to have the opportunity to sit down and talk with Matt Prekker, the lead author on the DEVICE trial evaluating video versus direct laryngoscopy for tracheal intubation which was published TODAY, June 2023, …
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Send us a Text Message (please include your email so we can respond!) Episode 11/12 (depending on how you count the ATS episode)! This time we discuss "Platelet Transfusion before CVC Placement in Patients with Thrombocytopenia" published in NEJM May 2023. Apologies for the lack of old articles, with summer travel plans we've prepped for a couple b…
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Send us a Text Message (please include your email so we can respond!) ATS 2023! Unfortunately for us, there were more breaking pulmonary articles compared to critical care but we did get this great article by the late Dr. Curtis published in JAMA during the conference "Intervention to Promote Communication About Goals of Care for Hospitalized Patie…
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Send us a Text Message (please include your email so we can respond!) Episode 10! In this episode we rambled a little bit and limited ourselves to just our new article which was "Haloperidol for the Treatment of Delirium in ICU Patients" published by Andersen-Ranberg et al in NEJM 2022. Of note, we go back and forth a little bit between "haloperido…
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Send us a Text Message (please include your email so we can respond!) Episode 9! In this episode we step a little out of our comfort zone to talk about a couple of analyses which caught our interest recently: 1) "Comparative Effectiveness of Fludrocortisone and Hydrocortisone vs Hydrocortisone Alone Among Patients With Septic Shock" published by Bo…
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Send us a Text Message (please include your email so we can respond!) Episode 8! In this episode we discuss NUTRIREA 3 or "Low versus standard calorie and protein feeding in ventilated adults with shock: a randomised, controlled, multicentre, open-label, parallel-group trial" by Reigner et al published Lancet Respiratory Medicine 2023. The "old" ar…
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Send us a Text Message (please include your email so we can respond!) Episode 7! In this episode we discuss CAPECOD or "Hydrocortisone in Severe Community-Acquired Pneumonia" by Dequin et al published NEJM 2023. No second article because this was an important trial which has a lot of messy history that we review, including the ESCAPe trial publishe…
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Send us a Text Message (please include your email so we can respond!) Episode 6! In this episode we discuss 1) "Treating Rhythmic and Periodic EEG Patterns in Comatose Survivors of Cardiac Arrest" by Ruijter et al published NEJM 2022 and 2) "Dexamethasone treatment for the acute respiratory distress synrome" by Villar et al published Lancet Respira…
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Send us a Text Message (please include your email so we can respond!) Episode 5! In this episode we again go to a new and old article 1) "Spontaneous-Breathing Trials with Pressure-Support Ventilation or a T-piece" by Thille et al published NEJM 2022 and 2) "Intravascular Complications of Central Venous Catheterization by Insertion Site" or "3SITES…
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Send us a Text Message (please include your email so we can respond!) EPISODE 4! In this episode we are SUPER excited to welcome friend of the podcast Whitney Gannon who is our local ECMO expert to talk about the inspiration for her research in ECMO (ECMO liberation and anticoagulation practices in ECMO) AND the INCEPTION trial, or the Early Extrac…
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Send us a Text Message (please include your email so we can respond!) BONUS Episode Time! Right after we started the podcast where one of the episodes was the TEAM trial for early mobilization, SCCM happened and there was yet another early mobilization trial. Since we just had an early mobility discussion we decided to drop our thoughts on this, ho…
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Send us a Text Message (please include your email so we can respond!) Episode 3! In this episode switch it up and review 2 NEW articles that published with SCCM 2023 1)"Early Restrictive or Liberal Fluid Management for Sepsis-Induced Hypotension" or CLOVERS by the PETAL Network published NEJM 2023 and 2) "Effect of Non-Invasive Ventilation After Ex…
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