The Science of Fear, Trauma & Relearning Safety

The Longevity Podcast: Optimizing HealthSpan & MindSpan

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This episode maps the biology of fear and trauma and explains why the brain can lock in threat after just a single experience—then shows how real healing requires replacing, not erasing, old associations. We break down the physiology of stress, the circuitry of fear learning, and the cognitive stories that shape how we interpret danger, safety, and meaning. The goal: a clear, evidence-based path to recovery using tools that reshape both body and brain.

We start by distinguishing stress, anxiety, and fear, then trace the HPA axis, adrenaline, cortisol, and gene-expression shifts that keep the body on high alert. You’ll learn how the amygdala acts as the threat hub, how it links to dopamine-driven salience, and how the prefrontal cortex becomes the storyteller that either amplifies or dissolves fear. We explain one-trial learning, maladaptive generalization, and why the gold-standard rule is extinction plus replacement—building a new association strong enough to override the old one.

The episode covers evidence-based therapies including prolonged exposure, CPT, CBT, and repetition-based relearning. We discuss the role of ketamine as a buffer that softens defensive responses and MDMA-assisted therapy for trust-driven emotional relearning. Finally, we highlight foundational supports—social connection, sleep, nutrition—along with cautions around cyclic hyperventilation and the stabilizing effects of saffron and inositol.

High-volume keywords used: trauma recovery, fear learning, anxiety, HPA axis, amygdala, exposure therapy, ketamine, MDMA-assisted therapy

Listener Takeaways

• How stress, anxiety, and fear differ in biology and experience
• Why one-trial learning locks in threat and drives generalization
• The rule of extinction + replacement for true trauma healing
• How exposure, CBT, ketamine, and MDMA assist relearning
• Foundational tools: sleep, connection, nutrition, saffron, inositol

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This podcast is created by Ai for educational and entertainment purposes only and does not constitute professional medical or health advice. Please talk to your healthcare team for medical advice.

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Bölümler

1. Defining Stress, Anxiety, And Fear (00:00:00)

2. The HPA Axis And Stress Hormones (00:01:56)

3. Amygdala, Dopamine, And Fear Loops (00:03:18)

4. Prefrontal Cortex And The Story Of Emotion (00:04:55)

5. One-Trial Learning And Generalization (00:06:12)

6. Extinction Plus Replacement As Core Strategy (00:08:06)

7. Evidence-Based Therapies And Repetition (00:09:30)

8. Ketamine And MDMA Assisted Relearning (00:11:00)