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The Addiction Medicine Podcast is designed for healthcare professionals and others interested in addiction medicine and will feature thoughtful conversations and insights from clinicians, patients and families, policymakers and other stakeholders.
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The Addiction Files: An Addiction Medicine Podcast

Darlene Petersen, MD and Paula Cook, MD

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Darlene Petersen, MD and Paula Donnelly Cook, MD are board certified addiction medicine and family medicine physicians providing evidence based education, clinical pearls and resources to physicians, residents and students while striving to destigmatize the treatment of addiction in our medical culture and save lives. Tune in to learn about the latest treatments for all things addiction. Join us as we conduct expert interviews, review clinical pearls and best practices and discuss the latest ...
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The Curbsiders Addiction Medicine Podcast

The Curbsiders Addiction Medicine Podcast

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SEASON 3 will launch July 18th, 2024! Step up your knowledge on caring for patients with substance use disorders (SUD)! This show features addiction medicine experts who are dedicated to bringing you practice changing knowledge about substance use, and substance use disorders. We use expert interviews to demystify common addiction medicine topics, reduce stigma, and inspire listeners to be fierce advocates for all individuals who use substances. This mini-series is hosted by Doctors Carolyn ...
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Addiction Medicine: Beyond the Abstract

American Society of Addiction Medicine

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An ideal opportunity for those interested in addiction medicine to get a closer look at the perspectives behind formal research articles. Podcasts offer insights into the experiences of the authors and researchers behind the great work and development in the field. Listening to their stories and thought processes helps listeners to connect with the experts behind the journal in a brand-new way. Hosted by Journal Podcast Editor, Shawn McNeil, MD
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In episode 47 we discuss the effectiveness of sublingual and injectable buprenorphine for patients with OUD, with and without fentanyl. Nunes EV, Comer SD, Lofwall MR, Walsh SL, Peterson S, Tiberg F, Hjelmstrom P, Budilovsky-Kelley NR. Extended-Release Injection vs Sublingual Buprenorphine for Opioid Use Disorder With Fentanyl Use: A Post Hoc Analy…
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Dr. Corey Waller, a nationally recognized expert in substance use disorder, explores the rapid evolution of SUD treatment over the past five years. He delves into the improved understanding of care delivery, the development of evidence-based treatment guidelines, and the critical role these advancements play in saving lives and enhancing patient ou…
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Brett Heselpoth, RN and case manager joins us to discuss patient engagement. What does that initial encounter look for patients and how do we link them to care. Join us for this fascinating episode hosted by Paula Donnelly Cook, MD and Darlene Petersen, MD. Check us out on facebook @Theaddictionfiles or twitter @THEADDICTIONFI1 or Instagram Theaddi…
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In Part 2 of our podcast episode on Sexually Transmitted Infections, we dive deeper into STI screening, prevention, and treatment with experts Dr. Shannon Dowler and Dr. Amy Marietta. 👀 Want to know: The must-know screening guidelines for ALL patients? How new meds like PrEP and Doxy PEP are changing prevention? Why partner treatment is a game-chan…
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In episode 46 we discuss using high doses of varenicline and nicotine for smoking cessation. Cinciripini PM, Green CE, Shete S, Minnix JA, Robinson JD, Cui Y, Kim S, Kypriotakis G, Beneventi D, Blalock JA, Versace F, Karam-Hage M. Smoking Cessation After Initial Treatment Failure With Varenicline or Nicotine Replacement: A Randomized Clinical Trial…
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Dr. Spencer Hansen joins us in an amazing episode. He teaches us essential listening skills that form the basis of life-saving safety planning—two critical therapeutic techniques we can all apply in bedside and clinic settings. Hosted by Darlene Petersen, MD and Paula Donnelly Cook, MD. Check us out on facebook @Theaddictionfiles or twitter @THEADD…
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Season 4 of the Addiction Medicine Podcast kicks off with a 2-part episode on Sexually Transmitted Infections (STI). In Part 1, we dive into how the term ‘infection’ can reduce stigma, encourage testing, and emphasize the importance of regular screenings. We also discuss current trends, cultural trends, health inequities, and the role of healthcare…
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Join us to hear the latest pearls and best practices on talking to patients about vaping, if e-cigarettes can be used to stop smoking cigarettes, and every other question you hadn’t thought to ask about vaping with Drs. Pam Ling (UCSF) and Maya Vijayaraghavan (UCSF). Claim CME for this episode at curbsiders.vcuhealth.org! By listening to this episo…
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From Recreational Use to Possible Therapeutic Interventions Learn how different hallucinogens act in the body and common dosing strategies. Appreciate the risks of use and the current state of hallucinogen research. We are joined in this episode by Dr. Albert Garcia-Romeu (Johns Hopkins Center for Psychedelic and Consciousness Research) Claim CME f…
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In the 1980s and 1990s, crack cocaine dominated the drug scene in the United States. It had devastating effects, destroying lives and communities while fueling mass incarceration. However, the story goes beyond mere addiction and criminality. In this episode we review the history of Crack, consequences of use and treatment. Hosted by Darlene Peters…
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Maximize your treatment of alcohol-associated liver disease. Learn how to evaluate liver disease in patients with alcohol use disorder (AUD), choose AUD medications that are safe and effective, and identify patients who may be eligible for early liver transplantation. We’re joined by Dr. Lamia Haque, @lykhaque (Yale School of Medicine). Claim CME f…
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Spark your learning We cover clinical pearls from graduating addiction medicine fellows by covering ACAAM’s annual lighting round presentation. Learn about tianeptine, buprenorphine starts in patients with acute hepatitis, vaccinations for persons who inject drugs, and more! Claim CME for this episode at curbsiders.vcuhealth.org! Listening to this …
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Today, we're tackling a growing concern: the misuse of caffeine and the booming popularity of energy drinks. Join us as we unpack the latest trends in caffeine consumption, from the skyrocketing sales of energy drinks to the ritualistic coffee culture that defines many societies. We’ll explore the fascinating science behind caffeine’s effects on th…
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Expand your practice to include wound care for xylazine-related wounds and learn how to talk to your patients about harm reduction for xylazine. We are joined by Dr. Raagini Jawa (@Raaginizzle, UPMC) and Tehya Johnson, NP (@TehyaRJohnson, Boston Health Care for the Homeless). Claim CME for this episode at curbsiders.vcuhealth.org! By listening to t…
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OTP yea you know me Make methadone a part of your practice. Learn how the methadone system in the US works and how you can play an active role in improving care for people with opioid use disorder treated with methadone. We’re joined by Dr. Ruth Potee @DrRuthPotee (website) and Dr. David Frank @highway_dave Claim free CME for this episode at curbsi…
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Join us as Dr. Mason Turner returns to educate on the fundamentals of psychotic disorders, with a focus on distinguishing Substance or Medication Induced Psychotic Disorder from primary psychotic disorders. We also cover treatment considerations, including delusional disorder and postpartum psychosis. Hosted by Darlene Petersen, MD, and Paula Donne…
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45. Urine Drug Screens and Treatment Retention In episode 45 we discuss urine drug screens and treatment retention. Michener PS, Knee A, Wilson D, Boama-Nyarko E, Friedmann PD. Association of random and observed urine drug screening with long-term retention in opioid treatment programs. Drug Alcohol Depend. 2024 Feb 1;255:111067. We also discuss st…
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Ray Sweet, MS joins us to discuss the devasting epidemic of suicide that disproportionately affects those with substance use disorders. Ray teaches us about risk and protective factors and community based coping strategies and more. Hosted by Paula Donnelly Cook, MD and Darlene Petersen, MD. Check us out on facebook @Theaddictionfiles or twitter @T…
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44. Cannabis and CV Outcomes In episode 44 we discuss the association between cannabis use and cardiovascular outcomes. Jeffers AM, Glantz S, Byers AL, Keyhani S. Association of Cannabis Use With Cardiovascular Outcomes Among US Adults. J Am Heart Assoc. 2024 Mar 5;13(5):e030178. doi: 10.1161/JAHA.123.030178. Epub 2024 Feb 28. We also discuss the D…
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We review Delta 8 THC, mechanism of actions, legal issues surrounding this drug and current trends surrounding use. Hosted by Paula Donnelly Cook, MD and Darlene Petersen, MD. Check us out on facebook @Theaddictionfiles or twitter @THEADDICTIONFI1 or Instagram Theaddictionfiles or email us at theaddictionfiles@gmail.com No explicit language but thi…
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In episode 43 we discuss prescribing medication for alcohol use disorder at hospital discharge. Bernstein EY, Et al. Outcomes After Initiation of Medications for Alcohol Use Disorder at Hospital Discharge. JAMA Netw Open. 2024 Mar 4;7(3):e243387. We also discuss grandparents raising grandchildren who’ve lost a parent to drug overdose, and how nativ…
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Podcast host Shawn McNiel, MD, is joined by Noa Krawczyk, PhD, an assistant professor in the Department of Population Health at NYU Grossman School of Medicine, and an author of Initiatives to Support the Transition of Patients With Substance Use Disorders From Acute Care to Community-based Services Among a National Sample of Nonprofit Hospitals. D…
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In episode 42 we discuss how buprenorphine protects against fentanyl overdose. Zheng Dai, et al. Quantifying a potential protective effect of buprenorphine on fatality risk during acute fentanyl exposures. Journal of Substance Use and Addiction Treatment, Volume 158, 2024. 209252, ISSN 2949-8759. We also discuss semaglutide for alcohol use disorder…
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Our very own Dr. Paula Cook and Lanette Denton join us to discuss their recent study on employing harm reduction in rural county jail. Hosted by Darlene Petersen, MD. Check us out on facebook @Theaddictionfiles or twitter @THEADDICTIONFI1 or Instagram Theaddictionfiles or email us at theaddictionfiles@gmail.com No explicit language but this podcast…
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In episode 41 we discuss vaping for smoking cessation. Auer R, et al. Electronic Nicotine-Delivery Systems for Smoking Cessation. N Engl J Med. 2024 Feb 15;390(7):601-610. We also discuss the NarxCare addiction risk score and the recent increase in alcohol-related deaths. New York Times: Addiction Risk Scores Won’t Solve the Opioid Crisis CDC: Deat…
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Quick summaries of Episodes 31-40. 31. Injection Drug Use Frequency Before and After Take-Home Naloxone Training 32. Trazodone for sleep disturbance in opioid dependent patients maintained on buprenorphine: A double blind, placebo-controlled trial 33. Non-fatal overdose risk associated with prescribing opioid agonists concurrently with other medica…
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April is alcohol awareness month. In this episode we review the stages of alcohol associated liver disease, signs and symptoms and laboratory abnormalities. Hosted by Paula Donnelly Cook, MD and Darlene Petersen, MD. Check us out on facebook @Theaddictionfiles or twitter @THEADDICTIONFI1 or Instagram Theaddictionfiles or email us at theaddictionfil…
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Xylazine Use Among People Who Inject Drugs, Philadelphia 2022 Host Shawn McNiel, MD, is joined by Marissa Tan, DO, an Epidemiology Intelligence Service (EIS) Fellow for the Center of Disease Control and Prevention through the Philadelphia Department of Public Health. Dr. Tan and her co-authors sought to help clinicians better identify individuals a…
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In this episode we discuss drug overdose after benzodiazepine prescriptions for anxiety and depression. Bushnell GA, et al. Drug overdose risk with benzodiazepine treatment in young adults: Comparative analysis in privately and publicly insured individuals. Addiction. 2023. We also talk about the war on recovery treatments and patients leaving the …
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Anna Lembke, MD joins us to discuss the Dopamine reward system in our brains and how the pleasure/pain balance affects addiction and recovery. This is a fascinating discussion. Hosted by Paula Donnelly Cook, MD and Darlene Petersen, MD. For more information on Dr. Lembke: www.annalembke.com Check out her New York Times best seller books "Dopamine N…
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In this episode we discuss improvements in cognitive function with opioid abstinence. Kaur, G. Et Al. Effects of Abstinence From Opioid on Neuropsychological Performance in Men With Opioid Use Disorder: A Longitudinal Study. Journal of Addiction Medicine 17(5): p 557-562, 9/10 2023. We also talk about paramedics giving buprenorphine along with nalo…
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Does varenicline reduce alcohol cravings? Tune in as we review the evidence, mechanism of action of varenicline. Hosted by Paula Donnelly Cook, MD and Darlene Petersen, MD. Check us out on facebook @Theaddictionfiles; X @THEADDICTIONFI1, TikTok, or Instagram @Theaddictionfiles or email us at theaddictionfiles@gmail.com No explicit language but this…
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In this episode we discuss 5 more articles that changed our addiction medicine practice. Chambers LC, et al. Buprenorphine Dose and Time to Discontinuation Among Patients With Opioid Use Disorder in the Era of Fentanyl. JAMA Netw Open. 2023; 6(9):e2334540. September 2023. (Episode 34) Caponnetto, P., et al. Varenicline and counseling for vaping ces…
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Mason Turner, MD returns to discuss depression and substance use disorders as part of our mental health and substance use disorders series. Dr. Turner gives us a primer on the types of depression, epidemiology of depression in substance using populations, treatment considerations and lifestyle interventions. Hosted by Darlene Petersen, MD and Paula…
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In this episode we discuss 5 articles that changed our addiction medicine practice. Mahdi Sheikh, et al. Postdiagnosis Smoking Cessation and Reduced Risk for Lung Cancer Progression and Mortality: A Prospective Cohort Study. Ann Intern Med.2021;174:1232-1239. [Epub 27 July 2021]. (Episode 4) Santos GM, et al. Targeted Oral Naltrexone for Mild to Mo…
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Steve Sugden, MD joins us to discuss lifestyle medicine and neuroplasticity in the recovery process. Hosted by Paula Donnelly Cook, MD and Darlene Petersen, MD. Check us out on facebook @Theaddictionfiles or twitter @THEADDICTIONFI1 or Instagram Theaddictionfiles or email us at theaddictionfiles@gmail.com No explicit language but this podcast discu…
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In episode 38 we discuss an article comparing different treatments (and no treatment) for opioid use disorder. Robert Heimer, Anne C. Black, Hsiuju Lin, Lauretta E. Grau, David A. Fiellin, Benjamin A. Howell, Kathryn Hawk, Gail D’Onofrio, William C. Becker. Receipt of Opioid Use Disorder Treatments Prior to Fatal Overdoses and Comparison to No Trea…
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George Koob, PhD director of NIAAA teaches us about the addiction cycle, the origins of "Hyperkatefia", review of treatment options during the negative affect cycle and how NIAAA is monitoring current policies and trends regarding alcohol use. Hosted by Paula Cook, MD and Darlene Petersen, MD. www.niaaa.nih.gov https://www.rethinkingdrinking.niaaa.…
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37. Injectable Vs. Sublingual Buprenorphine In episode 37 we discuss an article comparing injectable and sublingual buprenorphine. Superiority and cost-effectiveness of monthly extended-release buprenorphine versus daily standard of care medication: a pragmatic, parallel-group, open-label, multicentre, randomised, controlled, phase 3 trial. Marsden…
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Podcast host Shawn McNeil, MD, is joined by Joshua Sharfstein, MD, and Sara Whaley, MPH, from Johns Hopkins Bloomberg School of Public Health who delve into the strategic allocation of $56 billion from opioid litigation settlements. As they discuss the principles for effective fund utilization, they highlight opportunities for addiction medicine sp…
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Lucinda Grande MD, FASAM joins us to discuss her research on low dose ketamine for buprenorphine inductions with emphasis on transitions from fentanyl to buprenorphine. She discusses patient selection, dosing considerations, and safety profile. Hosted by Paula Donnelly Cook, MD and Darlene Petersen, MD. Check us out on facebook @Theaddictionfiles o…
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In episode 36 we discuss an article about the mediators of problematic smartphone use. Christiane Arrivillaga, Caleb J. Hallauer, Christian Montag, Jon D. Elhai. Emotion dysregulation factors associated with problematic smartphone use severity: The mediating role of fear of missing out. Addictive Behaviors. Volume 143. 2023. https://doi.org/10.1016…
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Dr. Javier Ballester joins us for our second episode on co-occurring mental health and substance use. We'll cover Bipolar, its prevalence with substance use disorders, diagnosis, and treatment considerations. Hosted by Paula Donnelly Cook, MD and Darlene Petersen, MD. Check us out on facebook @Theaddictionfiles or twitter @THEADDICTIONFI1 or Instag…
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In episode 35 we discuss whether eliminating prior auths leads to more buprenorphine prescribing. Christine PJ, Larochelle MR, Lin L, McBride J, Tipirneni R. Removal of Medicaid Prior Authorization Requirements and Buprenorphine Treatment for Opioid Use Disorder. JAMA Health Forum. 2023;4(10):e233549. We also discuss buprenorphine diversion, and th…
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Our year-end review in addiction medicine for 2023, covers key topics, including the 2022 NSDUH data, trends in xylazine and fentanyl, and the impact of social isolation on alcohol use. Hosted by Paula Donnelly Cook, MD and Darlene Petersen, MD. Check us out on facebook @Theaddictionfiles or twitter @THEADDICTIONFI1 or Instagram Theaddictionfiles o…
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In episode 24 we discuss prescribing 24 mg of buprenorphine daily. Chambers LC, Hallowell BD, Zullo AR, et al. Buprenorphine Dose and Time to Discontinuation Among Patients With Opioid Use Disorder in the Era of Fentanyl. JAMA Netw Open. 2023;6(9):e2334540. September 2023. We also discuss why Rite Aid filed for bankruptcy, and the FDA ban on mentho…
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In episode 28 of Addiction Medicine: Beyond the Abstract, host Shawn McNeil, MD is joined my Ashish Thakrar, MD, MS, an addiction medicine specialist and Assistant Professor of Medicine with the University of Pennsylvania. Dr. Thakrar discusses the outcome of his research, which aimed to determine whether fentanyl concentration is associated with t…
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We are excited to launch the first in our series on cooccurring mental health disorders and substance use disorders. Dr. Mason Turner joins us to discuss the prevalence of anxiety disorders in the substance using population. Types of anxiety disorders seen, treatment considerations and common pitfalls to avoid when managing patients with cooccurrin…
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In episode 33 we discuss overdose risk and polypharmacy: opioids, benzodiazepines, antipsychotics, and gabapentinoids. Domzaridou E, Carr MJ, Millar T, Webb RT, Ashcroft DM. Non-fatal overdose risk associated with prescribing opioid agonists concurrently with other medication: Cohort study conducted using linked primary care, secondary care and mor…
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We are discussing inhalant misuse, epidemiology, diverse routes of administration, the spectrum of substances subjected to misuse, and the ensuing ramifications, spanning both acute and chronic side effects. We review a spectrum of treatment modalities, ranging from emergency interventions and withdrawal management. Hosted by Paula Cook, MD and Dar…
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